Routine quality control of recycled target 18Owater by capillary electrophoresis and gas chromatography

You are viewing information about the paper Routine quality control of recycled target 18Owater by capillary electrophoresis and gas chromatography.

Journal: Nucl Med Biol 2003/09/23
Published: 2003
Authors: Huang, B. X.;Channing, M. A.;Plascjak, P. S.;Kiesewetter, D. O.;Der, M.;Ma, Y.;Eckelman, W. C.
Address: PET Department, Warren G. Magnuson Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA. bhuang@mail.cc.nih.gov

Recycling of (18)Owater for (18)Ffluoride production can be accomplished with reliable results. We have developed sensitive, robust, and rapid analyses of impurities in (18)Owater. Anions were quantitated by capillary electrophoresis and organic residuals were quantitated by gas chromatography using methods with excellent reproducibility and linearity. Kryptofix 222 (K-222) was quantitated by a sensitive LC-MS-MS technique. Isotopic composition was determined by GC-MS with satisfactory accuracy and precision. These methods were employed to evaluate recovered (18)Owater purified by a novel electrolysis method. 2-(18)FFDG yields using purified (18)Owater with very low levels of impurities are indistinguishable from newly purchased (18)Owater. High (> 300 ppm) carbonate concentration reduces the fluoride trapping efficiency of QMA. The analyses of anions, organics, and isotopic enrichment were applied routinely for quality control of (18)Owater to predict a satisfactory outcome of 2-(18)FFDG production.

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